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Articles by Sam Salman
Low-plastic diet and urinary levels of plastic-associated phthalates and bisphenols: the randomized controlled PERTH Trial
Abstract The everyday use of plastic products exposes us to plastic-associated chemicals (PACs), which have been associated with risks to human health. We present the results of the Plastic Exposure Reduction Transforms Health Trial, with an observational cohort of 211 Australian participants and a 7-day pilot randomized controlled trial in 60 participants.
Detection of phosphatidylethanol in an abstinent individual following blood transfusion
Data availability statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
High dose, subcutaneous injections of benzathine penicillin G (SCIP) to prevent rheumatic fever: a single arm, phase IIa trial of safety and pharmacokinetics
Keywords Rheumatic heart disease acute rheumatic fever penicillin BPG subcutaneous.injection Introduction Acute rheumatic fever (ARF) is a preventable immune-mediated inflammatory disease that occurs as a delayed sequelae to group A streptococcus (GAS; Streptococcus pyogenes) infections.1,2 ARF and its complication rheumatic heart disease (RHD) typically begin in childhood and have significant negative effects on health, often resulting in chronic illness, cardiac failure, stroke, and...
5 Simple Distractions to Lift Your Spirits
Sam Salman · Follow 3 min read · -- At precisely 12:30 PM, I was anxiously awaiting the rickshaw on the fourth floor to pick up my children. The driver arrived 10 minutes late, and I quickly rushed downstairs to board the rickshaw. Unfortunately, he took a wrong turn down a construction-ridden street. Another 10 minutes passed, and when I reached the school, I was met with a disheartening sight. My children looked upset, and my younger daughter, a mere 3.5 years old, was crying in her classroom.
Taste-Masked Flucloxacillin Powder Part 2: Formulation Optimisation Using the Mixture Design Approach and Storage Stability
3. Discussion In this study, the DoE approach was successfully applied to identify the composition of the FTM-MCR to meet the collective goal of minimising %R2, and maximising %R60 and %Ratio@6M. The compositional ranges within which the three components were constrained were well-defined in that they enabled the identification of the FTM-MCR within the design space.
Taste-Masked Flucloxacillin Powder Part 1: Optimisation of Fabrication Process Using a Mixture Design Approach
3. Discussion Using the Option 1 two-phase systems, a total of 3 mL of solvent was adequate to solubilise all three components, which was considerably smaller than the 25 mL of ethanol required to solubilise the single ternary-phase system.
LC‐MS/MS analysis of erythrocyte phosphatidylethanol in haematocrit‐corrected whole blood versus isolated erythrocytes: Results of an inter‐laboratory comparison
Phosphatidylethanol (PEth) is a non-oxidative metabolite of alcohol (ethanol), which is a sensitive and specific indicator of historic ethanol consumption. Although PEth production from ethanol is catalysed by the ubiquitous enzyme phospholipase D, it resides mainly within the erythrocyte compartment of the blood. PEth analysis has been reported in different preparations of whole blood, representing one of the barriers of inter-laboratory comparisons.
A systematic review of pregnancy-related clinical intervention of drug regimens due to pharmacokinetic reasons
Introduction Pregnant females are commonly prescribed medications for both pregnancy and non-pregnancy related disease states (1). Pregnancy does not exclude the need for pharmacotherapy, and proper control over a disease-state is essential, in some cases, to preventing poor fetal outcomes and the health of the females. In the United States (US), over 50% of pregnant females take at least one medication, and the national average ranges from 3 to 5 medications per pregnant female (2).
The future belongs to the connectors of dots
"At Huminn we look at problems as multifaceted yet one in essence, with researchers from different fields working together, sharing insights, and studying a problem from all perspectives simultaneously," writes Sam Salman, the Chairman & CEO of Huminn As the 21st century unfolds, the challenges facing humanity seem to only grow in scope, complexity, and severity.
Population Pharmacokinetic Study of Ceftriaxone in Elderly Patients, Using Cystatin C-Based Estimates of Renal Function To Account for Frailty
Pharmacology Shu Jin Tan, Matthew Cockcroft, Madhu Page-Sharp, Glenn Arendts, Timothy M. E. Davis, Brioni R. Moore, Kevin T. Batty, Sam Salman, Laurens Manning DOI: 10.1128/AAC.00874-20 ABSTRACT Ceftriaxone is widely used for respiratory and urinary infections in elderly and frail patients, but there are few pharmacokinetic studies. A prospective population pharmacokinetic study of ceftriaxone in adults over 65 years old was undertaken.
Defining the combined benefit of intermittent preventive malaria treatment in pregnancy
WHO has included intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine as an important malaria intervention since 2012. 1 WHO WHO policy brief for the implementation of intermittent preventive treatment of malaria in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP).
Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling
Publication HistoryPublished online: June 29, 2017Accepted: May 25, 2017; Received: February 27, 2017;
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