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Abstract Postoperative abdominal adhesions develop after most abdominal operations and remain a major source of long-term morbidity. Although thromboinflammation is increasingly recognized in adhesions pathobiology, its relationship with the peritoneal mesothelial cell (PMC) epithelial glycocalyx (EpGL) is poorly understood. Using a rat model of abdominal adhesions, severe adhesions were observed at early (24 h, 72 h) and late (14d) time points.
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Background Abdominal adhesions are the most common surgical complication and without reliable prophylactics. This study presents a novel rat model for abdominal adhesions and reports pilot results of human placental stem cell (hPSC)-based therapies. Methods Forty-four (n = 44) male Sprague–Dawley rats (250-350 g) were used in the experiment. Of these, thirty-eight (n = 38) were included in a preliminary data set to determine a minimum treatment effect.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
