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Samya Samanta

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Articles by Samya Samanta

Synthesis and Application of Bioactive N‐Functionalized Aziridines

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By Samya Samanta, Nan Qiu, Alexander Adibekian, David Powers
| Wiley Online Library Verified
1 Introduction Aziridines are the smallest saturated nitrogen-containing heterocycles and engage in strain-accelerated ring-opening chemistry with nucleophiles (Figure 1a).[1] Aziridines are not often encountered in natural products: While robust enzymatic machinery is available to construct epoxides, which are the oxygen analogues of aziridines, from olefinic precursors, analogous aziridination chemistry has not naturally evolved.[2] Despite the relative dearth of naturally occurring...
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β‐Phenethylamine Synthesis: N‐Pyridinium Aziridines as Latent Dual Electrophiles

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By Samya Samanta, Promita Biswas, Braeden O'Bannon, David Powers
| Wiley Online Library Verified
β-phenethylamines are oft-encountered structural motifs in biologically active compounds,1 including dopamine receptor agonists,2 various enzyme inhibitors,3 and are particularly prevalent in small-molecule therapeutics for central nervous system disorders,2b, 4 opioid receptor drugs,5 and analgesics.6 Fragment-based drug discovery campaigns,3a which rely on elucidation of quantitative structure–activity relationships, demand modular synthetic methods to diversify all the constituent...
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ß‐Phenethylamine Synthesis via Latent Dual Electrophilicity of N‐Pyridinium Aziridines

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By Samya Samanta, Promita Biswas, Braeden O'Bannon, David Powers
| pericles.pericles-prod.literatumonline.com
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
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