Pulmonary embolism (PE) care is entering a new chapter. In February 2026, a multisociety guideline introduced an A to E clinical classification framework and gave class I support for PE response team (PERT) assessment to improve in-hospital care—the first major update since the 2019 European Society of Cardiology guidelines.1,2 Because the guideline review preceded the first randomized mechanical thrombectomy trials, emerging evidence must be interpreted alongside its recommendations.
