Abstract Aims, Objectives and Background More than 4.9 million people in the UK have diabetes, and sufferers are at increased risk of depression.1 We reviewed enquiries to the NPIS about insulin overdose. Method and Design Retrospective analysis of enquiries between 1 November 2011 and 31 October 2021. Results and Conclusion We received 1195 enquiries involving insulin. Further analysis was limited to the 169 enquiries involving insulin only (90.5% via injection).