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Sandra Pong

As seen in: Nature, PLOS, BMJ Open
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Articles by Sandra Pong

Association of delayed adequate antimicrobial treatment and organ dysfunction in pediatric bloodstream infections - Pediatric Research

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By Sandra Pong
| Nature Verified
Abstract Bloodstream infections (BSIs) are associated with significant mortality and morbidity, including multiple organ dysfunction. We explored if delayed adequate antimicrobial treatment for children with BSIs is associated with change in organ dysfunction as measured by PELOD-2 scores. We conducted a multicenter, retrospective cohort study of critically ill children <18 years old with BSIs. The primary outcome was change in PELOD-2 score between days 1 (index blood culture) and 5.
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Antibiotic treatment duration for bloodstream infections in critically ill children-A survey of pediatric infectious diseases and critical care clinicians for clinical equipoise | PLOS ONE

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By Sandra Pong, Robert Fowler, Toronto Ontario
| PLOS
Treatment duration recommendations The majority of clinicians recommended at least 10 days of antibiotics for bacteremia associated with each of the infectious syndromes: pneumonia (84/129, 65%), skin/soft tissue (80/108, 74%), urinary tract (68/107, 64%), intra-abdominal (drained) (97/108, 90%) and intra-abdominal (undrained) (107/108, 99%). The most common treatment durations recommended for most infections were either 7, 10 or 14 days (full distributions displayed in Figs 1 and 2).
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Testing for non-inferior mortality: a systematic review of non-inferiority margin sizes and trial characteristics

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By Robert Fowler, Nicholas Mitsakakis, Sandra Pong
| BMJ Open Verified
Testing for non-inferior mortality: a systematic review of non-inferiority margin sizes and trial characteristics http://orcid.org/0000-0003-2963-9601Sandra Pong1, Martin Urner2,3, Robert A Fowler2,4, Nicholas Mitsakakis5, Winnie Seto1,6, James S Hutchison7, Michelle Science8, http://orcid.org/0000-0001-8827-3764Nick Daneman9 1Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada 2Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto,...
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