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Articles by Sanjay Ram
Pre-clinical efficacy of a candidate outer membrane vesicle gonococcal vaccine in comparison with 4CMenB
Abstract Neisseria gonorrhoeae causes 82 million global cases of gonorrhoea annually. Multidrug-resistant gonococci threaten to make gonorrhoea untreatable. Meningococcal vaccines MeNZB and 4CMenB (Bexsero), containing Neisseria meningitidis group B detergent-extracted outer membrane vesicles (dOMV), cross-protect against gonorrhoea with 31–59% effectiveness. We hypothesised that gonococcal OMV-based vaccines would have greater efficacy against gonorrhoea than meningococcal vaccines.
Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria - Nature Communications
Abstract Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dosing, frequency of administration and thereby potentially patient compliance.
[Sparta Coding Club] Week 3- Today I learned
Making a copy of Instagram clone using HTML, JS, and CSS was super exciting. I got to design how things look, style them, and add cool functions, which taught me a lot. It felt awesome to see my code in action and recreate Instagram features. Figuring out the details of HTML while imitating a famous platform made the whole development process even more fun!
In Vitro Pre-Clinical Evaluation of a Gonococcal Trivalent Candidate Vaccine Identified by Transcriptomics
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The “Black Fungus” in India: The Emerging Syndemic of COVID-19-Associated Mucormycosis
Mucormycosis is a rare disease caused by fungi of the order Mucorales (1). The agents of mucormycosis are ubiquitous environmental molds found in soil and decaying organic matter; exposure to airborne spores is commonplace, yet disease is very rare. In a susceptible person, spores germinate into hyphae, which then invade surrounding tissue, including blood vessels, resulting in hemorrhagic infarction.
Role of Gonococcal Neisserial Surface Protein A (NspA) in Serum Resistance and Comparison of Its Factor H Binding Properties with Those of Its Meningococcal Counterpart
Microbial Immunity and Vaccines Lisa A. Lewis, Peter A. Rice, Sanjay Ram Andreas J. Bäumler, Editor DOI: 10.1128/IAI.00658-18 ABSTRACT Neisseria gonorrhoeae, the causative agent of gonorrhea, has evolved several mechanisms to subvert complement, including binding of the complement inhibitor factor H (FH). We previously reported FH binding to N. gonorrhoeae independently of lipooligosaccharide (LOS) sialylation.
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