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1 Introduction Since its introduction more than 25 years ago, joint modeling (JM) of longitudinal and time-to-event (TTE) data has undergone significant methodological advancement and has been applied across a broad spectrum of scientific disciplines [1-7]. In the field of oncology precision medicine, it has been used to monitor disease progression, assess treatment response, enable real-time prognostication, and detect early signs of disease progression [8-13].
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