Highlights • The increasing prevalence of MS phenotypes signals an expanding healthcare burden. • PPMS and SPMS had significantly more prescriptions for symptom management vs RRMS. • Depression was the most common clinical condition associated with each phenotype. Abstract Background : A diagnosis of multiple sclerosis (MS) can be categorized based on its disease course into the following phenotypes: relapsing-remitting MS (RRMS), primary progressive MS (PPMS), and secondary progressive MS (SPMS).
