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Articles by Saran Long
Unveiling the Power of Dark State Photocages: An Efficient Pathway to Triplet State under Near‐Infrared Light Irradiation
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Nonconjugated Structural Distortion Promoting the Formation of NIR Triplet states in Phenothiazine Dyes for Cancer Photoimmunotherapy
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Activating Iterative Revolutions of the Cancer‐Immunity Cycle in Hypoxic Tumors with a Smart Nano‐Regulator
The activation of sequential events in the cancer-immunity cycle (CIC) is crucial for achieving effective anti-tumor immunity. However, formidable challenges, such as innate and adaptive immune resistance, along with the off-target adverse effects of non-selective immunomodulators, persist.
Aryl‐Modified Pentamethyl Cyanine Dyes at the C2’ Position: A Tunable Platform for Activatable Photosensitizers
1 Introduction Cyanine, originally proposed as a classic imaging chromophore, is favorable among existing dyes because it combines high extinction coefficients (>105 M−1 cm−1), good biocompatibilities, and high water solubilities.[1] Within the cyanine family, the pentamethyl cyanine dye (Cy5) exhibits near-infrared absorption and emission (>650 nm), in addition to an excellent photostability, thereby rendering it one of the best candidates for fluorescence imaging, sensing, and photodynamic...
A near-infrared GPX4 fluorescent probe for non- small cell lung cancer imaging
A near-infrared GPX4 fluorescent probe for non- small cell lung cancer imaging Qiao Hu, Wanjie Zhu, Jianjun Du, Saran Long, Wen Sun, Jiangli Fan and Xiaojun Peng Abstract Glutathione peroxidase 4 (GPX4) is overexpressed in non-small cell lung cancer (H1299) cells. In this work, a near-infrared fluorescent probe ENBO-ML210 was developed.
ER-Targeting Cyanine Dye as an NIR Photoinducer to Efficiently Trigger Photoimmunogenic Cancer Cell Death
Endoplasmic reticulum (ER) stress, caused by overproduction of reactive oxygen species (ROS), has been shown to be responsible for immunogenic cell death (ICD). Seeking ROS generator targeting ER is an optimal solution to efficiently induce ER stress. Despite clear indications of demand for ER-targeting photosensitizer, the alternative chemical tools remain limited.
New Cy5 photosensitizers for cancer phototherapy: low singlet-triplet gap provides high quantum yield of singlet oxygen
New Cy5 photosensitizers for cancer phototherapy: low singlet-triplet gap provides high quantum yield of singlet oxygen He Ma, Saran Long, Jianfang Cao, Feng Xu, PanWang Zhou, Guang Zeng, Xiao Zhou, Chao Shi, Wen Sun, Jianjun Du, Keli Han, Jiangli Fan and Xiaojun Peng Abstract Highly efficient triplet photosensitizers (PSs) have attracted increasing attention in cancer photodynamic therapy where photo-induced reactive oxygen (ROS, such as singlet oxygen) produces via singlet-triplet...
An Approach to Developing Cyanines with Simultaneous Intersystem Crossing Enhancement and Excited-State Lifetime Elongation for Photodynamic Antitumor Metastasis
Heavy-atom-based photosensitizers usually exhibit shortened triplet-state lifetimes, which is not ideal for hypoxic tumor photodynamic therapy. Although several heavy-atom-free photosensitizers possess long triplet-state lifetimes, the clinical applicability is limited by their short excitation wavelengths, poor photon capture abilities, and intrinsically hydrophobic structures.
Oxygen-Dependent Regulation of Excited-State Deactivation Process of Rational Photosensitizer for Smart Phototherapy
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Development of A Novel Anti-tumor Theranostic Platform: Near-Infrared Molecular Upconversion Sensitizer for Deep-seated Cancer Photodynamic Therapy
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Nitroxyl-responsive near-infrared fluorescent chemosensor for visualizing H2S/NO crosstalk in biological systems
Nitroxyl-responsive near-infrared fluorescent chemosensor for visualizing H2S/NO crosstalk in biological systems We present a near-infrared (NIR) fluorescent probe, NR-HNO, which was successfully applied to visualizing H2S/NO “crosstalk” by fluorescence detecting nitroxyl with fast response (5 min) and large Stokes shifts (131 nm) in living cells and tissue, and was also used to image nitroxyl in live mice. You have access to this article Please wait while we load your content...
Negatively charged metal-organic hosts with cobalt dithiolene species: Improving PET processes for light-driven proton reduction through host-guest electrostatic interactions
Negatively charged metal-organic hosts with cobalt dithiolene species: Improving PET processes for light-driven proton reduction through host-guest electrostatic interactions By incorporating 1,2-benzenedithiol as a chelator to construct cobalt dithiolene species, two negatively charged redox-active metal-organic hosts were obtained.
In Situ Imaging of Aminopeptidase N Activity in Hepatocellular Carcinoma: A Migration Model for Tumour Using an Activatable Two-Photon NIR Fluorescent Probe
CD13/aminopeptidase N (APN), which is a zinc-dependent metalloproteinase, plays a vital role in the growth, migration, angiogenesis, and metastasis of tumours. Thus, in suit molecular imaging of endogenous APN levels is considerably significant for investigating APN and its different functions. In this study, a novel two-photon near-infrared (NIR) fluorescence probe DCM-APN was prepared to perform in vitro and in vivo tracking of APN.
Synthesis of an ultrasensitive BODIPY-derived fluorescent probe for detecting HOCl in live cells
Hypochlorous acid (HOCl) is a critical member of the reactive oxygen species (ROS) produced by immune cells to fight infections. On the other hand, HOCl in homeostasis causes oxidative damage to biomolecules and is linked to many diseases, including inflammatory, neurodegenerative, and cardiovascular diseases. Herein, we detail a procedure for the preparation of a boron-dipyrromethene (BODIPY)-derived fluorescent probe for HOCl (BClO) and its application as an imaging reagent in living cells.
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