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Synthesis of Diversely Substituted Quinazoline-2,4(1H,3H)-diones by Cyclization of tert-Butyl (2-Cyanoaryl) Carbamates The synthesis of diversely substituted quinazoline-2,4(1H, 3H)-diones by cyclization of tert-butyl (2-cyanoaryl) carbamates using readily accessible Boc protected o-amino nitriles is reported. The reaction proceeds smoothly at room temperature using just 1 equiv. of H2O2 as an oxidant under basic conditions.
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