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Scott Witte

As seen in: MDPI, BioRxiv
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Articles by Scott Witte

Action-At-A-Distance in DNA Mismatch Repair: Mechanistic Insights and Models for How DNA and Repair Proteins Facilitate Long-Range Communication

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By Scott Witte, Carol M Manhart, Bryce W. Collingwood
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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The Mlh1-Pms1 endonuclease uses ATP to preserve DNA discontinuities as strand discrimination signals to facilitate mismatch repair

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By Jonathan Piscitelli, Scott Witte, Yasmine S Sakinejad, Carol M Manhart
| BioRxiv
Abstract In eukaryotic post-replicative mismatch repair, MutS homologs (MSH) detect mismatches and recruit MLH complexes to nick the newly replicated DNA strand upon activation by the replication processivity clamp, PCNA. This incision enables mismatch removal and DNA repair. Biasing MLH endonuclease activity to the newly replicated DNA strand is crucial for repair.
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Frank Lloyd Wright's Taliesin. A Guided 360 VR Virtual Tour

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By Scott Witte
| tourdeforce360.com
This 360 Virtual Visit samples what can be seen and heard on various tours offered at Taliesin East. Many schools use it as a virtual field trip. Unlike still or video, 360 Virtual Reality lets you experience the place as if you were there. This tour offers something extra - a couple viewpoints not available to the public. For instance, visitors aren't allowed in the Blue Loggia. Foot traffic would damage the irreplaceable Chinese rug, So they never see the balcony above or the rug up close.
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