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Highlights 4• The spike characteristics of EEG are valuable in CECTS. 4• The spike clearance velocity on serial EEGs is related to the rate of seizure recurrence. 4• Spike clearance velocity might be a valuable EEG marker to guide anti-seizure medication. Abstract Purpose To assess the spike characteristics and temporal spike evolution on serial EEG of children with childhood epilepsy with centrotemporal spikes (CECTS) treated with anti-seizure medication.
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