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Projected Benefit of Bilateral Salpingo-Oophorectomy by Age in BRCA Carriers Key Points Question What is the residual lifetime risk of ovarian cancer for BRCA carriers according to age at the time of bilateral salpingo-oophorectomy (BSO)? Findings In this study, we analyzed prospective data from 5713 BRCA carriers and applied the life table approach to estimate the residual ovarian cancer risk according to variant type, current age, and projected age at BSO.
Objective The purpose of this study was to recontact individuals with clinically actionable test results identified through a retrospective research study and to provide a framework for laboratories to recontact patients. Methods Genetic testing was conducted on 2977 individuals originally referred for BRCA1 and BRCA2 hereditary breast and ovarian cancer testing that had a negative genetic test result.
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