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Abstract Glioblastoma (GBM) is the most aggressive primary brain tumor, characterized by high recurrence rates and poor prognosis despite multimodal treatment. Understanding the mechanisms underlying GBM relapse is crucial for developing more effective therapeutic strategies. In vitro relapse models provide controlled environments to investigate tumor recurrence, therapeutic resistance, and disease progression.
Abstract The reduced effectiveness of chemotherapy in many patients highlights the need for novel drug combinations and optimal ratios that target multiple survival mechanisms, which tumors may engage to confer drug resistance. Dynamic conditions within the tumor microenvironment shape cell behavior and influence the response to anti-cancer drugs, varying by cell type and local context.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
