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Senyan Wang

As seen in: Nature, Wiley Online Library, Frontiers in Immunology
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Articles by Senyan Wang

Sepsis transcriptomics and validation identify PFKFB2 as a regulator of early inflammation and later lactate-dependent M2-like programming in LPS-stimulated macrophages

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By Tiancai Zhang, Yuxiao Zhang, Xinze Li, Qi Liu, Dong Xu, Bo Cui, Mengyao Yu, Senyan Wang, Huapeng Zhang, Dongqing Dou
| Nature Verified
Abstract Sepsis involves dynamic immune dysfunction and metabolic reprogramming, but the role of lactylation-associated metabolic genes in macrophage responses remains unclear. We integrated four peripheral-blood transcriptomic datasets using differential expression analysis, weighted gene co-expression network analysis, and four machine-learning algorithms.
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Frontiers | Integrated multi-omics, spatial profiling and organoid modeling drive transformative advances in chronic liver disease and hepatocellular carcinoma immunomicroenvironment research

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By Qi Liu, Chenyu Wang, Huawei Zhang, Wenjuan Wei, Senyan Wang, Huapeng Zhang
| Frontiers in Immunology
1 Introduction Chronic liver diseases(CLDs), including viral hepatitis, metabolic dysfunction-associated steatotic liver disease(MASLD), and autoimmune liver diseases, collectively represent a major global health burden (1). Their progressive nature often leads to liver fibrosis, cirrhosis, and hepatocellular carcinoma(HCC). Central to this pathogenesis is the persistent dysregulation and remodeling of the hepatic immune microenvironment—a highly heterogeneous and dynamic ecosystem (2).
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Multifunctional Hydrogel Microneedle Patches Modulating Oxi‐inflamm‐aging for Diabetic Wound Healing

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By Shen Tian, Jiawei Mei, Lisha Zhang, Senyan Wang
| Wiley Online Library Verified
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202407340-sup-0001-SuppMat.pdf1.3 MB Supporting Information References 1, , , , , APL Bioeng. 2021, 5, 031503. 2, , , , , Medicina 2021, 57, 1072. 3a) , , Acc. Chem. Res. 2021, 54, 1080; b) , , , , Biomater. Sci. 2019, 7, 2652; c) , , , , , , Adv. Therapeut. 2023, 6, 2300002. 4a) , , , , Int. J. Mol. Sci. 2017, 18, 1545; b) , , , , Physiol. Rev. 2019, 99, 665. 5a) , , Am. J. Pathol.
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Multifunctional Hydrogel Microneedle Patches Modulating Oxi‐inflamm‐aging for Diabetic Wound Healing

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By Shen Tian, Jiawei Mei, Lisha Zhang, Senyan Wang
| pericles.pericles-prod.literatumonline.com
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202407340-sup-0001-SuppMat.pdf1.3 MB Supporting Information References 1, , , , , APL Bioeng. 2021, 5, 031503. 2, , , , , Medicina 2021, 57, 1072. 3a) , , Acc. Chem. Res. 2021, 54, 1080; b) , , , , Biomater. Sci. 2019, 7, 2652; c) , , , , , , Adv. Therapeut. 2023, 6, 2300002. 4a) , , , , Int. J. Mol. Sci. 2017, 18, 1545; b) , , , , Physiol. Rev. 2019, 99, 665. 5a) , , Am. J. Pathol.
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