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Abstract PRESERVE-003 is a two-stage phase 3 trial evaluating gotistobart (BNT316/ONC-392), a novel pH-sensitive anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4) antibody that selectively depletes regulatory T cells within the tumor microenvironment, in patients with metastatic squamous non-small cell lung cancer (sqNSCLC) without actionable genomic alterations who progressed on programmed cell death protein/programmed death ligand 1 inhibitor/platinum-based chemotherapy—a population...
INTRODUCTION Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme that degrades tryptophan (Trp) to kynurenine (Kyn), which may suppress effector T cells and activate T-regulatory cells (Tregs), and thus reduce antitumor immune responses.1, 2 High-IDO1 expression in tumors may create a barrier, and prevent penetration of active effector T cells.3 Thus, IDO1 inhibition may cause antigen-presenting cell activation, effector T-cell tumor penetration, and antitumor immune response...
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