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S.‐H. Kim

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Articles by S.‐H. Kim

Metabolomic analysis identifies potential diagnostic biomarkers for aspirin‐exacerbated respiratory disease

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By G.‐Y. Ban, K. Y. Cho, S.‐H. Kim, HospitalSeoul Korea
| Wiley Online Library Verified
Summary Background To date, there has been no reliable in vitro test to diagnose aspirin‐exacerbated respiratory disease (AERD). Objective To investigate potential diagnostic biomarkers for AERD using metabolomic analysis. Methods An untargeted profile of serum from asthmatics in the first cohort (group 1) comprising 45 AERD, 44 patients with aspirin‐tolerant asthma (ATA), and 28 normal controls was developed using the ultra‐high‐performance liquid chromatography (UHPLC)/Q‐ToF MS system.
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Neutrophil autophagy and extracellular DNA traps contribute to airway inflammation in severe asthma

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By D. Pham, Y. S. Shin, G.‐Y. Ban, S.‐H. Kim
| Wiley Online Library Verified
Summary Background Autophagy and neutrophil extracellular DNA traps (NETs) are implicated in asthma; however, their roles in asthma pathogenesis have not been elucidated. Objectives We compared autophagy and NET production levels from peripheral blood neutrophils (PBNs) of patients with severe asthma (SA) and non‐severe asthma (NSA). Additionally, we investigated the inflammatory effects of NETs on human airway epithelial cells (AECs) and peripheral blood eosinophils (PBEs).
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