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Abstract Psychiatric, neurodevelopmental, and neurodegenerative disorders, including Alzheimer’s disease (AD), attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BIP), major depressive disorder (MDD), and schizophrenia (SCZ), exhibit complex etiologies driven by immune and metabolic dysregulation. While distinct in their clinical onset, these conditions share overlapping molecular vulnerabilities.
AD Alzheimer's disease ADNI Alzheimer's disease neuroimaging initiative APP amyloid precursor protein AUC area under the curve Aβ amyloid-β BBB blood–brain barriers ceRNA competing endogenous RNA CNS central nervous system DEG differential expression gene DMP differentially methylated position eQTL expression quantitative trait loci ETC the electron transport chain GBA gut-brain axis GEO gene expression omnibus GLM generalized linear model GO Gene ontology GSEA gene set enrichment analysis...
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