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Abstract Background: Antimicrobial resistance (AMR) is a critical global challenge, with an estimated ≥10 million deaths per year by 2050. Klebsiella pneumoniae (K. pneumoniae), a critical priority bacterial pathogen, is rapidly developing resistance even against next-generation (meropenem) and last-resort (colistin) antibiotics, whereas the pipeline for discovery and development of new antibiotic(s) for treatment of antibiotic-resistant K.
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Abstract Immunization is expected to confer protection against infection and severe disease for vaccines while reducing risks to unimmunized populations by inhibiting transmission.
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