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Articles by Shanjun Deng
Longitudinal lineage tracing reveals early clonal attrition during Drosophila midgut aging
Loading metrics Open Access Peer-reviewed Research Article Citation: Gong H, Liu K, Deng S, Wang J, He X, Liu L (2026) Longitudinal lineage tracing reveals early clonal attrition during Drosophila midgut aging. PLoS Biol 24(6): e3003866.
Polyclonal-to-monoclonal transition in colorectal precancerous evolution - Nature
Abstract Unravelling the origin and evolution of precancerous lesions is crucial for effectively preventing malignant transformation, yet our current knowledge remains limited1,2,3. Here we used a base editor-enabled DNA barcoding system4 to comprehensively map single-cell phylogenies in mouse models of intestinal tumorigenesis induced by inflammation or loss of the Apc gene.
Photoacoustic Tomography with Temporal Encoding Reconstruction (PATTERN) for cross-modal individual analysis of the whole brain - Nature Communications
Abstract Cross-modal analysis of the same whole brain is an ideal strategy to uncover brain function and dysfunction. However, it remains challenging due to the slow speed and destructiveness of traditional whole-brain optical imaging techniques. Here we develop a new platform, termed Photoacoustic Tomography with Temporal Encoding Reconstruction (PATTERN), for non-destructive, high-speed, 3D imaging of ex vivo rodent, ferret, and non-human primate brains.
A statistical method for quantifying progenitor cells reveals incipient cell fate commitments - Nature Methods
Abstract Quantifying the number of progenitor cells that found an organ, tissue or cell population is of fundamental importance for understanding the development and homeostasis of a multicellular organism. Previous efforts rely on marker genes that are specifically expressed in progenitors. This strategy is, however, often hindered by the lack of ideal markers.
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