Research Article | Therapeutics and Prevention Shaochun Chen, Kristie L. Connolly, Corinne Rouquette-Loughlin, Alexander D’Andrea, Ann E. Jerse, William M. Shafer Richard Gerald Brennan, Editor DOI: 10.1128/mBio.01576-19 ABSTRACT Neisseria gonorrhoeae has developed resistance to every antibiotic introduced for treatment of gonorrhea since 1938, and concern now exists that gonorrheal infections may become refractory to all available antibiotics approved for therapy.