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Abstract While loss of Y chromosome (LOY), a common somatic alteration with aging, has been associated with cardiovascular diseases, its specific impact on ST-segment elevation myocardial infarction (STEMI) remains underexplored. This study enrolled 928 males undergoing primary percutaneous coronary intervention for STEMI to investigate the impact of LOY in blood cells on all-cause mortality. LOY was measured in males using droplet digital polymerase chain reaction technique.
This prospective cohort study was conducted in a large-volume national tertiary care institute (Fuwai Hospital, Beijing) specializing in cardiovascular diseases. Between March 2017 and January 2020, 1403 patients (age ≥ 18 years) who underwent emergent coronary angiography and CHIP examinations due to the diagnosis of STEMI (symptom onset ≤ 24 h before presentation) were prospectively enrolled.
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