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Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Chen S, Zhou J, Wang S, Chen E, Zhuang K, Lin R, et al. (2025) Gnb5 is a negative regulator of the BACE1-mediated Aβ generation and ameliorates cognitive deficits in a mouse model of Alzheimer’s disease. PLoS Biol 23(6): e3003259.
Editor’s summary Ancient DNA has revealed a great deal about our history, especially admixture events with archaic hominins. However, DNA degrades much faster than other biomolecules such as proteins. Ancient proteomics may enhance our ability to study remains that are older and in environments inhospitable to DNA. Fu et al. analyzed ancient proteomic data from a 146,000-year-old cranium from Harbin, China.
1 Introduction DNA N6-methyladenine (6mdA) is a predominant epigenetic mark in prokaryotes.[1, 2] In recent years, 6mdA was proposed to exist in many multicellular eukaryotes, including fungi,[3] C.
Article27 June 2023 Source DataTransparent process Shaokun ChenWeiyi LaiYanan LiYan LiuJie JiangXiangjun LiGuibin JiangHailin Wang Abstract Intracellular decay of N6-methyladenine (m6A)-containing RNA potentially induces aberrant N6-methyl-2′-adenine (6mdA) misincorporation into DNA. Biophysically, misincorporated 6mdA may destabilize the DNA duplex in a manner similar to bona fide methylated 6mdA DNA, thereby affecting DNA replication and transcription.
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