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Shaomin Qian

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Articles by Shaomin Qian

Inhibition of focal adhesion kinase impairs tumor formation and preserves hearing in a murine model of NF2-related schwannomatosis

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By Zhen Zhang, Ling Xiao, Jaideep Pathak, Dana Mitchell, Li Jiang, Henry Mang, Waylan K. Bessler, Xiaohong Li, Qingbo Lu, Shaomin Qian, Eric York, Christopher F. Davis, Ka-Kui Chan, Abbi E. Smith, Victor LE, Sarah K. Morrow, Alyssa C. Flint, Anna Geisinger
| Science Magazine Verified
Abstract NF2 (neurofibromatosis type 2)–related schwannomatosis (NF2-SWN) is a cancer predisposition syndrome characterized by the development of bilateral vestibular (VS) and spinal schwannomas. While benign, these tumors can cause substantial morbidity, and effective pharmacological treatments remain limited. Here, we demonstrate that genetic ablation of focal adhesion kinase (Fak/Ptk2) impairs tumor formation and preserves hearing in a murine model of NF2.
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TGFβ-dependent signaling drives tumor growth and aberrant extracellular matrix dynamics in NF1-associated plexiform neurofibroma

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By Jessica Kirshner, Philip Woods, Ben Title, Mohannad Abu-Sultanah, Zhuan Zhou, Chunhui Jiang, Dana Mitchell, Li Jiang, Xiaohong Li, Abbi E. Smith, Henry Mang, Emily White, Brooke Hickey, George Sandusky, Mohannad Abu-Sultanah, Waylan K. Bessler, Shaomin Qian, Marisa D. Ciesielski
| Science Magazine Verified
Abstract Plexiform neurofibromas (PNFs) are benign tumors of the peripheral nervous system that represent a major source of morbidity in neurofibromatosis type 1 (NF1). A substantial proportion of patients do not respond to current therapies or experience intolerable side effects.
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