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Shaoru Wang

As seen in: Chemistry World
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Articles by Shaoru Wang

The m6A methylation perturbs Hoogsteen pairing-guided incorporation of an oxidized nucleotide

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By Xiang Zhou, Shaoru Wang, Yafeng Wang, Yanyan Song
| Royal Society of Chemistry Verified
Natural nucleic acid bases can form Watson-Crick (WC) or Hoogsteen (HG) base pairs. Importantly, 8-oxo-2’-deoxyguanosine (8-oxo-dG) in DNA or 8-oxo-dG 5’-triphosphate (8-oxo-dGTP) favors a syn conformation because of the steric repulsion between O8 and O4’ of the deoxyribose ring. 8-oxo-dGTP can be incorporated into DNA opposite the templating adenine (A) using HG pairing as the dominant mechanism. Both RNA and DNA can be methylated at the N6 position of A to form N6-methyladenine (m6A).
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Epigenetic modification of nucleic acids: from basic studies to medical applications

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By Yuqi Chen, Tingting Hong, Shaoru Wang, Jing Mo
| Royal Society of Chemistry Verified
The epigenetic modification of nucleic acids represents one of the most significant areas of study in the field of nucleic acids because it makes gene regulation more complex and heredity more complicated, thus indicating its profound impact on aspects of heredity, growth, and diseases.
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N 6-Methyladenine hinders RNA- and DNA-directed DNA synthesis: application in human rRNA methylation analysis of clinical specimens

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By Molecular Sciences, Shaoru Wang, Jiaqi Wang
| Chemistry World Verified
N -Methyladenine (m A) is the most abundant internal modification on mammalian mRNA. Very recently, m A has been reported as a potentially important ‘epigenetic’ mark in eukaryotes. Until now, site-specific detection of m A is technically very challenging. Here, we first reveal that m A significantly hinders DNA- and RNA-directed DNA synthesis. Systematic investigations of 5′-triphosphates of a variety of 5-substituted 2′-deoxyuridine analogs in primer extension have been performed.
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