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Integrins are conformationally flexible cell surface receptors that survey the extracellular environment for their cognate ligands. Interactions with ligands are thought to be linked to global structural rearrangements involving transitions between bent, extended-closed and extended-open forms. Thus far, structural details are lacking for integrins in the extended conformations due to extensive flexibility between the headpiece and legs in this conformation.
Cryo-electron microscope at West Campus brings unprecedented capabilities to Yale, spurring science and faculty recruitment Microscopy at Yale has just received a major upgrade. Structural biologists at the School of Medicine and scientists from across the university have begun obtaining three-dimensional images at near-atomic resolutions from what Jorge E. Galán, Ph.D., D.V.M., chair and Lucille P.
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