Abstract Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a family of RNA-binding proteins that are highly involved in nucleic-acid metabolism. The pathological effect of a series of hnRNPs family members on ovarian cancer is far from fully elucidated. This study acquired the RNA-seq data of ovarian cancer and imformation about hnRNP from TCGA database and a published study, respectively. The expression, mutation and copy number variation (CNV) of 22 hnRNP genes were analyzed.