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Shinji Kamada

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Articles by Shinji Kamada

Repurposed endogenous virus-like vesicles mediate dendritic cell long-range antigen presentation and T cell activation for enhanced cancer vaccination

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By Wenchao Gu, Ruoxin Li, Dorin Artzi, Simian Cai, Yi-Chih Tsai, Guoting Qin, Ann Li, Nadine Elkasri, Sijin Luozhong, Shinji Kamada, Yizhou Wu, Yanru Cui, Vaibhav Upadhayay, Yu Zhao, Justin Lau Verified, Chenzhi Cai, Qiuming Yu, Shaoyi Jiang, Hayleigh Goodrich, Aixin Shi, Evelyn Goldwasser, Ella Sultan, Alexei Wirganowicz
| Nature Verified
Abstract Dendritic cells release extracellular vesicles (DEVs) that amplify antigen presentation while incorporating patient-derived, rapidly evolving antigens. By enriching peptide–major histocompatibility complex (MHC) and co-stimulatory ligands orders of magnitude above donor-cell levels, DEVs emerge as potent vesicle-vaccines, although efficacy remains limited by unclear mechanisms.
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Lysine-specific demethylase 1 (LSD1) suppresses cellular senescence by riboflavin uptake-dependent demethylation activity - Scientific Reports

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By Shinji Kamada
| Nature Verified
Abstract Cellular senescence is defined as a permanent proliferation arrest caused by various stresses, including DNA damage. We have recently identified the riboflavin transporter SLC52A1, whose expression is increased in response to senescence-inducing stimuli. Interestingly, increased expression of SLC52A1 suppresses cellular senescence through the uptake of riboflavin and an increase in intracellular flavin adenine dinucleotide (FAD), an enzyme cofactor synthesized from riboflavin.
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