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1. Introduction and Historical Perspective The word sepsis comes from the Greek word “σήψις,” meaning decomposition or decay. Its first documented use was over 2700 years ago when it appeared in Homer’s poems and was later utilized in the work of Hippocrates and Galen []. When the “Germ theory” of disease was developed in the 1800s, there was some recognition that sepsis is caused by dangerous micro-organisms.
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