Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Shoken Lee
Screening of amphipathic helices identifies features linked to inner nuclear membrane properties
Abstract Inner nuclear membrane (INM) proteins control numerous nuclear functions, yet properties governing peripheral INM-association remain poorly defined. Here, we perform an image-based screen to identify features in candidate and established amphipathic helices (AHs) that mediate INM association. AHs that localize to ER/Golgi membranes become INM-associated when directed to the nucleus, whereas mitochondrial-localized AHs become largely nucleoplasmic.
Parameters for sensing lipid loosening at the inner nuclear membrane by amphipathic helices
Abstract Amphipathic helices (AHs) detect differences in bulk membrane properties, but how AHs detect the nuclear membrane surrounding the genome is not well understood. Here, we computationally screened for candidate AHs in a curated list of characterized and putative human inner nuclear membrane (INM) proteins.
The Evolutionary Origins and Ancestral Features of Septins
Abstract Septins are a family of membrane-associated cytoskeletal GTPases that play crucial roles in various cellular processes, such as cell division, phagocytosis, and organelle fission. Despite their importance, the evolutionary origins and ancestral function of septins remain unclear. In opisthokonts, septins form five distinct groups of orthologs, with subunits from multiple groups assembling into heteropolymers, thus supporting their diverse molecular functions.
Differential reliance of CTD-nuclear envelope phosphatase 1 on its regulatory subunit in ER lipid synthesis and storage
Abstract The endoplasmic reticulum (ER) is the site for the synthesis of the major membrane and storage lipids. Lipin 1 produces diacylglycerol, the lipid intermediate critical for the synthesis of both membrane and storage lipids in the ER. CTD-Nuclear Envelope Phosphatase 1 (CTDNEP1) regulates lipin 1 to restrict ER membrane synthesis, but its role in lipid storage in mammalian cells is unknown.
A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope
Lipid composition determines organelle identity; however, whether the lipid composition of the inner nuclear membrane (INM) domain of the ER contributes to its identity is not known. Here, we show that the INM lipid environment of animal cells is under local control by CTDNEP1, the master regulator of the phosphatidic acid phosphatase lipin 1.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Shoken
Contact Shoken, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack