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Abstract The clinical effect of adjunctive intra-arterial tenecteplase after successful recanalization in acute basilar artery occlusion (BAO) remains uncertain.
Abstract In patients with acute ischemic stroke caused by medium vessel occlusion (MeVO), intra-arterial tenecteplase may offer a targeted strategy to improve recanalization; we hypothesized that intra-arterial tenecteplase would increase successful reperfusion compared with standard care with a comparable safety profile.
Abstract Intra-arterial tenecteplase during endovascular treatment (EVT) may increase first-pass recanalization and dissolve microcirculatory thrombi, but its efficacy and safety are uncertain. We hypothesised that this strategy would improve functional outcomes versus EVT alone. This phase 3, randomised, adaptive-enrichment, open-label, blinded-endpoint multicentre study aims to evaluate whether intra‑arterial tenecteplase improves clinical outcomes for patients with acute ischemic stroke.
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