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Abstract Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury, driven by oxidative stress and disruption of mitochondrial and lysosomal homeostasis. While transcription factor EB (TFEB) is a known master regulator of autophagy and antioxidant pathways, the upstream mechanism that triggers its activation during APAP hepatotoxicity remains unclear.
We report a new method for the synthesis of trifluoromethylated and sulfonylated oxazolines by electrochemical radical cascade cyclizations of N-allylamides with sodium trifluoromethanesulfinate or sulfonylhydrazines. This protocol provides a green and useful strategy to synthesize trifluoromethylated and sulfonylated oxazolines with a broad substrate scope under ambient conditions.
Electrosynthesis of (Hetero)aryl Nitriles from α-Imino-oxy Acids via Oxidative Decarboxylation/N-O Cleavage Hui-Shan Lin, Shu-Jun Chen and Jing-Mei Huang Abstract A new method for the synthesis of (hetero)aryl nitriles via iminyl radicals has been developed through electrochemical oxidative decarboxylation of α-imino-oxy acids.
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