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1 Introduction Parkinson’s disease (PD) is a prevalent neurodegenerative disorder characterized by cardinal motor symptoms, including tremor, rigidity, and bradykinesia. As the disease progresses, an increasing proportion of patients develop cognitive impairment, which may eventually evolve into Parkinson’s disease with cognitive impairment (PDCI).
1 Introduction PD is the second most common neurodegenerative disease globally, imposing an increasingly heavy burden on public health. It is characterized by progressive dopaminergic neuron degeneration in the nigrostriatal pathway and clinically presents with debilitating motor dysfunction (Jankovic 2008). Due to the overlapping PD phenotypes and the lack of objective biomarkers, the diagnosis remains uncertain, leading to delayed interventions and soaring medical costs.
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