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1 INTRODUCTION Neuroinflammation is implied in the initiation and pathological process of dementia, such as Alzheimer's disease (AD) (Heneka et al., 2015; Tran et al., 2022), and microglia play critical roles in neuroinflammation (Salter & Stevens, 2017; Wu, Sun, et al., 2013; Wu, Zhu, et al., 2013). As highly plastic cells, microglia can be derived into neurotoxic or neuroprotective phenotypes when exposed to stimuli.
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