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1 Introduction Metabolites are increasingly recognized as active chemical signals that regulate protein function through covalent post-translational modifications (PTMs) [1, 2]. Lysine acylations derived from metabolic intermediates [3], such as acetylation [4, 5], aminoacylation [6], succinylation [7], lactylation [8-10], and pyruvylation [11] have emerged as key mechanisms linking metabolic state to chromatin regulation, transcription, and cellular signaling.
1 Introduction Metabolites are increasingly recognized as active chemical signals that regulate protein function through covalent post-translational modifications (PTMs) [1, 2]. Lysine acylations derived from metabolic intermediates [3], such as acetylation [4, 5], aminoacylation [6], succinylation [7], lactylation [8-10], and pyruvylation [11] have emerged as key mechanisms linking metabolic state to chromatin regulation, transcription, and cellular signaling.
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