Solovyeva, O. et al. (2023) Development of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE study. BMC Medicine, 21, 246. (doi: 10.1186/s12916-023-02937-0) Text 302304.pdf - Published Version Available under License Creative Commons Attribution. 1MB Abstract Background: Early phase dose-finding (EPDF) trials are crucial for the development of a new intervention and influence whether it should be investigated in further trials.