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Abstract Heroin is an opioid agonist commonly abused for its rewarding effects. Since its synthesis at the end of the nineteenth century, its popularity as a recreational drug has ebbed and flowed. In the last three decades, heroin use has increased again, and yet the pharmacology of heroin is still poorly understood. After entering the body, heroin is rapidly deacetylated to 6-monoacetylmorphine (6-MAM), which is then deacetylated to morphine.
Research Articles, Neurobiology of Disease The Affective and Neural Correlates of Heroin versus Cocaine Use in Addiction Are Influenced by Environmental Setting But in Opposite Directions Silvana De Pirro, Gaspare Galati, Luigi Pizzamiglio and Aldo Badiani Journal of Neuroscience 30 May 2018, 38 (22) 5182-5195; DOI: https://doi.org/10.1523/JNEUROSCI.0019-18.2018
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