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Silvanus Alt

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Articles by Silvanus Alt

Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis

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By Hendrik A. Messal, Silvanus Alt, Christopher Gribben
| Nature Verified
Abstract Tubular epithelia are a basic building block of organs and a common site of cancer occurrence1,2,3,4. During tumorigenesis, transformed cells overproliferate and epithelial architecture is disrupted. However, the biophysical parameters that underlie the adoption of abnormal tumour tissue shapes are unknown.
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Differential lateral and basal tension drive folding of <i>Drosophila</i> wing discs through two distinct mechanisms

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By Martin Weigert, Liyuan Sui, Silvanus Alt, Natalie Dye
| Nature Verified
To analyze the overall three-dimensional shape changes during H/H and H/P fold formation over time, we developed a protocol for live imaging of wing imaginal discs in culture (Methods). Cultured wing imaginal discs sustained cell proliferation for at least 10 h (Supplementary Fig. 1m, Supplementary Movie 1) and formed H/H and H/P folds with no visible difference in shape from the hinge folds of fixed wing imaginal discs (Supplementary Figure 1n–q, Supplementary Movie 1).
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