Simin Sun
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Articles by Simin Sun
High burden of vitamin D deficiency in Chinese university students: impact of sun protection culture
Abstract Background: Vitamin D serves a critical function in preserving human physiological well-being and is mainly synthesized within the skin through sunlight exposure. In China, the traditional cultural preference for fair skin is associated with widespread sun avoidance among many individuals, including university students, who seek to prevent skin tanning.
Genetics and pathophysiology of diffuse idiopathic skeletal hyperostosis
Abstract Diffuse Idiopathic Skeletal Hyperostosis (DISH) is a systemic condition primarily characterized by flowing ossification along the anterolateral aspects of the spine, often leading to back pain, dysphagia, and an increased risk of spinal fractures. Despite its significant clinical burden and high prevalence among the elderly, DISH remains underdiagnosed and poorly understood, with no disease-modifying therapies currently available.
Design, Synthesis, and Anti-inflammatory Activity Evaluation for Hydrazide-Based HDAC6 Targeted Protein Degraders
Cite Jump to ExpandCollapse ArticleNovember 11, 2025 Design, Synthesis, and Anti-inflammatory Activity Evaluation for Hydrazide-Based HDAC6 Targeted Protein Degraders Click to copy article linkArticle link copied! Simin Sun Simin Sun Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266071, China NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug, Qilu Hospital of Shandong University,...
Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD
1 Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic liver disease characterized by the accumulation of excess fat in the liver, independent of excessive alcohol consumption.[1] The spectrum of MASLD ranges from simple metabolic dysfunction-associated steatohepatitis (MASH).[2] As the disease progresses, it may further develop into liver fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC).[3] The pathological mechanisms underlying the...
Discovery, Total Synthesis, and Anti‐Inflammatory Evaluation of Naturally Occurring Naphthopyrone‐Macrolide Hybrids as Potent NLRP3 Inflammasome Inhibitors
Conflict of interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Difluorocarbene in Cycloadditions and Annulations for the Synthesis of gem‐Difluorocarbocycles and gem‐Difluoroheterocycles
Conflict of interest The authors declare no conflict of interest. References 1 1a, , Bioorganic and Medicinal Chemistry of Fluorine, Wiley, Hoboken, 2008; 1b, J. Med. Chem. 2008, 51, 4359–4369; 1c, , , , , , , , Chem. Rev. 2014, 114, 2432–2506; 1d, , , , , , , , , Chem. Rev. 2016, 116, 422–518. 2 2aF. Babudri, G. M. Farinola, F. Naso, R. Ragni, Chem. Commun. 2007, 1003–1022; 2b, Chem. Soc. Rev. 2007, 36, 2070–2095. 3, , , , , Chem. Rec. 2023, 23, e202300283. 4, , , , Chem. Pharm. Bull. 1989, 37, 1173–1175. 5S.
Difluorocarbene in Cycloadditions and Annulations for the Synthesis of gem‐Difluorocarbocycles and gem‐Difluoroheterocycles
Conflict of interest The authors declare no conflict of interest. References 1 1a, , Bioorganic and Medicinal Chemistry of Fluorine, Wiley, Hoboken, 2008; 1b, J. Med. Chem. 2008, 51, 4359–4369; 1c, , , , , , , , Chem. Rev. 2014, 114, 2432–2506; 1d, , , , , , , , , Chem. Rev. 2016, 116, 422–518. 2 2aF. Babudri, G. M. Farinola, F. Naso, R. Ragni, Chem. Commun. 2007, 1003–1022; 2b, Chem. Soc. Rev. 2007, 36, 2070–2095. 3, , , , , Chem. Rec. 2023, 23, e202300283. 4, , , , Chem. Pharm. Bull. 1989, 37, 1173–1175. 5S.
Discovery of a Novel Ubenimex Derivative as a First-in-Class Dual CD13/Proteasome Inhibitor for the Treatment of Cancer
1. Introduction CD13/aminopeptide N (APN, EC 3.4.11.2) is a 150 kDa zinc-dependent type II metalloprotease that is expressed on various tissues and cell types, particularly on the membranes of tumor cells, such as multiple myeloma, liver cancer, melanoma, ovarian cancer, prostate cancer, colon cancer, pancreatic cancer, breast cancer, and lung cancer cells [1,2,3]. CD13 is considered a “moonlighting ectoenzyme” due to its multiple functions [4].
Discovery of Novel 2,3-Dihydro-1H-indene-5-sulfonamide NLRP3 Inflammasome Inhibitors Targeting Colon as a Potential Therapy for Colitis
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Med. Chem. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Adsorption of Reactive Red 120 in Decamethyl-Cyclopentasiloxane Non-Aqueous Dyeing System
Abstract : Traditional dyeing usually consumes a significant amount of water and salts, thus causing environmental pollution. Salt-free and low-water dyeing has become an important research direction in the cotton fabric dyeing industry. The non-aqueous media dyeing technology, using decamethylcyclopentasiloxane (D5) as the dyeing medium, has achieved energy saving and emission reduction in this industry.
Microwave-mediated stereocontrolled annulations of diazo(aryl)methyl(diaryl)phosphine oxides with pyridinium 1,4-zwitterionic thiolates
Microwave-mediated stereocontrolled annulations of diazo(aryl)methyl(diaryl)phosphine oxides with pyridinium 1,4-zwitterionic thiolates† Simin Sun, a Yuliang Weia and Jiaxi Xu *a Abstract Chemoselective annulations of phosphoryl carbenes generated from diazo(aryl)methyl(diaryl)phosphine oxides with pyridinium 1,4-zwitterionic thiolates were performed under microwave irradiation, affording 1-diarylphosphoryl-1H-benzo[c]thiopyran derivatives via [3+3] annulation and indolizine derivatives via...
Microwave-mediated stereocontrolled annulations of diazo(aryl)methyl(diaryl)phosphine oxides with pyridinium 1,4-zwitterionic thiolates
Microwave-mediated stereocontrolled annulations of diazo(aryl)methyl(diaryl)phosphine oxides with pyridinium 1,4-zwitterionic thiolates Simin Sun, Yuliang Wei and Jiaxi Xu Abstract Chemoselective annulations of phosphoryl carbenes generated from diazo(aryl)methyl(diaryl)phosphine oxides with pyridinium 1,4-zwitterionic thiolates were achieved under microwave irradiation, affording 1-diarylphosphoryl-1H-benzo[c]thiopyran derivatives via [3+3] annulation and indolizine derivatives via ([1+5]-1)...
Experimental evidence on the formation of highly strained 6,7‐dihydroazeto[2,1‐b]oxazol‐3‐iums as reactive intermediates
Full Paper Wenlai Xie, Beijing University of Chemical Technology, College of Chemistry, 15 Northern 3rd Ring Road East, Chaoyang District, 100029 Beijing, CHINA Search for more papers by this author Simin Sun, Beijing University of Chemical Technology, College of Chemistry, 15 Northern 3rd Ring Road East, Chaoyang District, 100029 Beijing, CHINA Search for more papers by this author Jiaxi Xu, Corresponding Author jxxu@mail.buct.edu.cn Beijing University of Chemical Technology, College of...
Experimental evidence on the formation of highly strained 6,7‐dihydroazeto[2,1‐b]oxazol‐3‐iums as reactive intermediates
Full Paper Wenlai Xie, Wenlai Xie Beijing University of Chemical Technology, College of Chemistry, 15 Northern 3rd Ring Road East, Chaoyang District, 100029 Beijing, CHINA Search for more papers by this author Simin Sun, Simin Sun Beijing University of Chemical Technology, College of Chemistry, 15 Northern 3rd Ring Road East, Chaoyang District, 100029 Beijing, CHINA Search for more papers by this author Jiaxi Xu, Corresponding Author Jiaxi Xu jxxu@mail.buct.edu.cn Beijing University of...
Transition metal-free access to 3,4-dihydro-1,2-oxaphosphinine-2-oxides from phosphonochloridates and chalcones through tandem Michael addition and nucleophilic substitution
Transition metal-free access to 3,4-dihydro-1,2-oxaphosphinine-2-oxides from phosphonochloridates and chalcones through tandem Michael addition and nucleophilic substitution A novel and transition metal-free synthesis of 3,4-dihydro-1,2-oxaphosphinine 2-oxides was developed.
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