Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
DAT dopamine transporter ICP intracavernosal pressure l-NOARG NG-nitro-l-arginine MAP mean arterial pressure NAT noradrenaline transporter PDE5 phosphodiesterase type 5 SERT serotonin transporter What is already known An estimated 40% of patients with erectile dysfunction have no improvement with currently available treatments. What does this study add The monoamine reuptake inhibitor, IP2015, stimulates erection via a central dopaminergic mechanism and NO-mediated peripheral relaxation.
Antipsychotics and erectile function Most antipsychotic drugs bind to and antagonize the effect of dopamine at dopamine D2 receptors, for example haloperidol. Therefore, older anti-psychotic drugs are often associated with decreased erection and anorgasmia in 30–60% of the patients, while newer anti-psychotics appear to have lower incidence of sexual dysfunction 5, 62.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
