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Articles by Simon Faissner
Severe cerebellitis as a manifestation of infliximab-associated overlap of neurosarcoidosis and myelin oligodendrocyte glycoprotein antibody-associated disease – case report
Abstract Background: Tumor necrosis factor-α (TNF-α) inhibitors such as infliximab are widely used in autoimmune disorders. Paradoxical inflammatory reactions including systemic sarcoidosis and neurosarcoidosis are increasingly recognized but remain rare. Case presentation: We report a 56-year-old male with ulcerative colitis under infliximab therapy presenting with acute dysarthria and gait instability. Neurological examination revealed truncal ataxia. Brain and spinal MRI were normal.
Effects of Biological Sex and Age on Cerebrospinal Fluid Markers-A Retrospective Observational Study
1 Introduction CSF analysis is a diagnostic procedure regularly performed in everyday clinical practice to detect and confirm neurological diseases [1-5]. CSF analysis is essential for the detection of an inflammatory or autoimmune process, the diagnosis of a neurodegenerative process such as Alzheimer's disease, the diagnosis of a neoplastic neurological disease as well as a computed tomography (CT) negative subarachnoid hemorrhage [2, 3, 5, 6].
Endocarditis following ocrelizumab in relapsing-remitting MS
Ocrelizumab is a monoclonal anti-CD20 antibody targeting B cells, which is authorized for relapsing-remitting MS (RRMS) and active primary progressive MS. Here, we report, to the best of our knowledge, the first case of infective endocarditis in a patient treated with ocrelizumab. Case report A 43-year-old man was admitted due to clinical deterioration within the last 4 weeks. He complained about worsening of gait and progressive weakness, aggravated double vision, and night sweats.
Innate Immunity in the Central Nervous System: A Missing Piece of the Autoimmune Encephalitis Puzzle?
Introduction Central nervous system (CNS) autoimmunity is a rapidly advancing field, with significant recent advances in our knowledge of the underlying mechanisms of disease. However, there remains significant gaps in our knowledge, particularly in the genesis of autoimmunity within the CNS and the interaction between the innate and adaptive arms of the immune response.
Progressive multiple sclerosis: from pathophysiology to therapeutic strategies
Abstract Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that involves demyelination and axonal degeneration. Although substantial progress has been made in drug development for relapsing–remitting MS, treatment of the progressive forms of the disease, which are characterized clinically by the accumulation of disability in the absence of relapses, remains unsatisfactory.
Multi-target-Directed Phenol-Triazole Ligands as Therapeutic Agents for Alzheimer’s Disease
Alzheimer’s disease (AD) is a multifactorial disease that is characterized by the formation of intracellular neurofibrillary tangles and extracellular amyloid-? (A?) plaque deposits. Increased oxidative stress, metal ion dysregulation, and the formation of toxic A? peptide oligomers are all considered to contribute to the etiology of AD. In this work we have developed a series of ligands that are multi-target-directed in order to address several disease properties.
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