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Abstract Inflammatory responses are associated with recruitment of monocyte-derived cells (Mdcs) into tissues. Although tissue-specific Mdc reprogramming is well established, how Mdc infiltration alters tissue metabolism remains unclear.
Abstract Cerebral disease manifestation occurs in about two thirds of males with X-linked adrenoleukodystrophy (CALD) and is fatally progressive if left untreated. Early histopathologic studies categorized CALD as an inflammatory demyelinating disease, which led to repeated comparisons to multiple sclerosis (MS). The aim of this study was to revisit the relationship between axonal damage and myelin loss in CALD.
Research Article Roberta Magliozzi Corresponding Author E-mail address: https://orcid.org/0000-0001-8284-7763 Neurology B, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom Correspondence Roberta Magliozzi, Neurology B, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy.
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