Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Simon Lind
Profiling of HCAR1 signalling reveals Gα
Ago-PAM agonist-positive allosteric modulator 3,5-DHBA 3,5-dihydroxybenzoic acid BRET bioluminescence resonance energy transfer ebBRET enhanced bystander BRET GPR81 G protein-coupled receptor 81 HCAR1 hydroxycarboxylic acid receptor 1 PAM positive allosteric modulator What is already known Lactate can act as a signalling molecule through HCAR1, influencing lipolysis and insulin sensitivity.
Profiling of HCAR1 signaling reveals Gαi/o and Gαs activation without β-arrestin recruitment and the discovery of an allosteric agonist
Abstract Lactate was long considered a byproduct of glycolysis and associated with various harmful effects. However, the role of lactate was expanded with the finding that it also can act as a signaling molecule through the G protein-coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor was shown to be primarily expressed in adipocytes but is also expressed in many other tissues and cell types.
[2405.04278] Uncertainty Quantification Metrics for Deep Regression
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
The allosterically modulated FFAR2 is transactivated by signals generated by other neutrophil GPCRs
PLOS ONE, Apr 2023 This is a preview of a remote PDF: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0268363&type=printable Simon Lind, Kenneth L. Granberg, Huamei Forsman, Claes Dahlgren. , PLOS ONE, 2023, Volume 18, Issue 4, DOI: 10.1371/journal.pone.0268363
At-home Sleep Monitoring Using Generic Ear-EEG
Yousef R. Tabar1*, Kaare B. Mikkelsen1, Nelly Shenton2, Simon L. Kappel1, Astrid R. Bertelsen2, Reza Nikbakht2, Hans O. Toft2, Chris H. Henriksen2, Martin C. Hemmsen2, Mike L.
Structural Determinants in the Staphylococcus aureus-Derived Phenol-Soluble Modulin α2 Peptide Required for Neutrophil Formyl Peptide Receptor Activation | The Journal of Immunology
Moa Viklund, Johanna Fredriksson, André Holdfeldt, Simon Lind, Henrik Franzyk, Claes Dahlgren, Martina Sundqvist and Huamei Forsman J Immunol April 1, 2022, 208 (7) 1632-1641; DOI: https://doi.org/10.4049/jimmunol.2101039 Key Points Neutrophils and FPR knock-in/knockout cells provide insights into receptor recognition. The S. aureus peptide PSMα2 is an FPR2 agonist that triggers biased signaling. Peptide parts that confer FPR1/FPR2 selectivity and alter signaling are identified.
Structural Determinants in the Staphylococcus aureus-Derived Phenol-Soluble Modulin α2 Peptide Required for Neutrophil Formyl Peptide Receptor Activation | The Journal of Immunology
Moa Viklund, Johanna Fredriksson, André Holdfeldt, Simon Lind, Henrik Franzyk, Claes Dahlgren, Martina Sundqvist and Huamei Forsman J Immunol March 23, 2022, ji2101039; DOI: https://doi.org/10.4049/jimmunol.2101039 Key Points Neutrophils and FPR knock-in/knockout cells provide insights into receptor recognition. The S. aureus peptide PSMα2 is an FPR2 agonist that triggers biased signaling. Peptide parts that confer FPR1/FPR2 selectivity and alter signaling are identified.
Identification of Residues Critical for FPR2 Activation by the Cryptic Peptide Mitocryptide-2 Originating from the Mitochondrial DNA-Encoded Cytochrome b | The Journal of Immunology
Simon Lind, Michael Gabl, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, Kodai Nishino, Claes Dahlgren, Hidehito Mukai and Huamei Forsman J Immunol May 1, 2019, 202 (9) 2710-2719; DOI: https://doi.org/10.4049/jimmunol.1900060 Key Points Critical structural elements are identified in MCT-2 that mediate FPR2 activation. MCT-2 polymorphic variants activate human neutrophils with different potency.
Identification of Residues Critical for FPR2 Activation by the Cryptic Peptide Mitocryptide-2 Originating from the Mitochondrial DNA-Encoded Cytochrome b | The Journal of Immunology
Simon Lind, Michael Gabl, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, Kodai Nishino, Claes Dahlgren, Hidehito Mukai and Huamei Forsman J Immunol March 22, 2019, ji1900060; DOI: https://doi.org/10.4049/jimmunol.1900060 Key Points Critical structural elements are identified in MCT-2 that mediate FPR2 activation. MCT-2 polymorphic variants activate human neutrophils with different potency.
Mitocryptides from Human Mitochondrial DNA-Encoded Proteins Activate Neutrophil Formyl Peptide Receptors: Receptor Preference and Signaling Properties | The Journal of Immunology
Mitocryptides from Human Mitochondrial DNA–Encoded Proteins Activate Neutrophil Formyl Peptide Receptors: Receptor Preference and Signaling Properties Michael Gabl, Martina Sundqvist, Andre Holdfeldt, Simon Lind, Jonas Mårtensson, Karin Christenson, Takayuki Marutani, Claes Dahlgren, Hidehito Mukai, Huamei Forsman The Journal of Immunology May 1, 2018, 200 (9) 3269-3282; DOI: 10.4049/jimmunol.1701719
Mitocryptides from Human Mitochondrial DNA-Encoded Proteins Activate Neutrophil Formyl Peptide Receptors: Receptor Preference and Signaling Properties | The Journal of Immunology
Mitocryptides from Human Mitochondrial DNA–Encoded Proteins Activate Neutrophil Formyl Peptide Receptors: Receptor Preference and Signaling Properties Michael Gabl, Martina Sundqvist, Andre Holdfeldt, Simon Lind, Jonas Mårtensson, Karin Christenson, Takayuki Marutani, Claes Dahlgren, Hidehito Mukai, Huamei Forsman The Journal of Immunology March 30, 2018, ji1701719; DOI: 10.4049/jimmunol.1701719
Reveal feature explanation on hover
cssAudio - Activefile-genericCSS - ActiveGeneric - ActiveHTML - ActiveImage - ActiveJS - ActiveSVG - ActiveText - Activefile-genericVideo - ActiveLovehtmlicon-new-collectionicon-personicon-teamlog-outoctocatpop-outspinnerstartv <!-- Had an idea for a hover-to-reveal-more interaction for a landing page section that I'm working on. It looks sort of okay, but the idea seemed cooler in my head.
Teaching with Technology - CNBC Africa
Technology has come to schools. All over Africa, schools and teachers are faced with the dilemma of how to use technology in the classroom. Technology enhances both teaching and learning but rapid technological advances mean that teachers, even in schools with meagre resources, can be faced with a bewildering array of systems and software that they are told will make teaching much easier. It doesn’t matter what the system or software is, or who the manufacturer is.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Simon
Contact Simon, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack