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Articles by Simon Sander
Publisher Correction: Design, structure-based optimization and antiviral evaluation of potent inhibitors for the macrodomain Mac1 of SARS-CoV-2
Correction to: Nature Communications https://doi.org/10.1038/s41467-026-75835-7, published online 27 July 2026 In this article, the single line connecting the “1” and “2” labels in the Figure 1 (ADPR) structure was missing. The figure should have appeared as shown below. The original article has been corrected.
Design, structure-based optimization and antiviral evaluation of potent inhibitors for the macrodomain Mac1 of SARS-CoV-2
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Abstract Enzymatically active macrodomains of (+)ss-RNA viruses mediate immune evasion by countering ADP-ribosylation and are therefore promising druggable targets. Here we report testing of ADP / ADP-ribose analogues for their ability to inhibit Mac1 of SARS-CoV-2, measurement of the affinity of active compounds and characterization of their binding mode by cocrystallization, uncovering critical molecular determinants of protein-ligand interaction.
By Maximilian Sandmann, Simon Sander, David Carrillo, Benedikt Ganter, Celine J. Fischer, Neele Pekarek, Julia M. Berger, Toni Luise Meister, Bruno Canard, Joanna M Watt, Barry Potter, Chris Meier, Sahra Tajdar, Marina Ocenas, Stefanie Etzold, Barbara Selisko, Maria Garcia Alai, Tidow Henning, Pfefferle Susanne, Ralf Fliegert
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Nature
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Master corepressor inactivation through multivalent SLiM-induced polymerization mediated by the oncogene suppressor RAI2 - Nature Communications
Abstract While the elucidation of regulatory mechanisms of folded proteins is facilitated due to their amenability to high-resolution structural characterization, investigation of these mechanisms in disordered proteins is more challenging due to their structural heterogeneity, which can be captured by a variety of biophysical approaches. Here, we used the transcriptional master corepressor CtBP, which binds the putative metastasis suppressor RAI2 through repetitive SLiMs, as a model system.
Brimonidine eye drops reveal diminished sympathetic pupillary tone in comatose patients with brain injury
Acta Neurochirurgica, Apr 2023 This is a preview of a remote PDF: https://link.springer.com/content/pdf/10.1007/s00701-023-05569-8.pdf Jakobsen, Elisabeth Waldemar, Nersesjan, Vardan, Albrechtsen, Simon Sander, Othman, Marwan H., Amiri, Moshgan, Knudsen, Niels Vendelbo, Larson, Merlin D., Hassager, Christian, Møller, Kirsten, Kjaergaard, Jesper, Kondziella, Daniel. , Acta Neurochirurgica, 2023, pp. 1-12, DOI: 10.1007/s00701-023-05569-8
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