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Articles by Simone Hashimoto
Reply to Erdem Topal
Editor: Philippe Eigenmann No abstract is available for this article. DATA AVAILABILITY STATEMENT Data sharing not applicable to this article as no datasets were generated or analysed during the current study. REFERENCES 1, , . Comment on Metwally NKA et al. Pediatr Allergy Immunol. 2026. 2, , , et al. Bronchodilator response is linked with uncontrolled moderate-to-severe childhood asthma and elevated IL-4 and IL-13.
Early-life antibiotic use and children with overweight and obesity: a Dutch twin cohort study
Abstract The number of children with obesity has risen over the decades, becoming a major public health concern, also because of persistence into adulthood and morbidity. Early-life antibiotic use alters gut microbiota composition, potentially causing metabolic disturbances, increasing the number of children with obesity.
Bronchodilator response is linked with uncontrolled moderate-to-severe childhood asthma and elevated IL-4 and IL-13
In children with moderate-to-severe asthma, a high bronchodilator response serves as a simple, noninvasive marker of poor disease control and a distinct systemic inflammatory signature characterized by elevated IL-4 and IL-13, supporting precision phenotyping and targeted treatment strategies.
Uncovering Non-Invasive Biomarkers in Paediatric Severe Acute Asthma Using Targeted Exhaled Breath Analysis
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Fatigue in severe pediatric asthma patients: Results of the PANDA study
High levels of fatigue are present in 4 out of 10 children with severe asthma. This demonstrates fatigue is an important patient-reported outcome and highlights the need for systematically assessing and treating this symptom in clinical practice. 1 INTRODUCTION Asthma is the most prevalent chronic pediatric condition, imposing a considerable burden on patients with severe disease.
Characteristics of severe asthma patients on biologics: a real-life European registry study
Analysis For the first aim, a descriptive analysis was performed to evaluate the patient clinical characteristics in different countries. Data were stratified per country and summarised using proportions and mean±SD. For the second aim, data from the SHARP registry were compared with data derived from RCTs using the Welch-modified t-test for continuous and χ2 tests for categorical variables.
Cumulative corticosteroid-sparing effect of anti-interleukin-5/5Ra in eosinophilic asthma
Discussion This real-world study shows that anti-IL-5/5Ra add-on treatment for severe eosinophilic asthma leads to a significant reduction in cumulative OCS exposure in the majority of patients. Furthermore, OCS exposure increases progressively in the years prior to anti-IL-5/5Ra initiation and declines rapidly after initiating anti-IL-5/5Ra therapy. More than half of the patients are able to completely eliminate OCS within 2 years of initiating anti-IL-5/5Ra therapy.
Cumulative Corticosteroid Sparing Effect of Anti-Interleukin-5/5Ra In Eosinophilic Asthma
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Severe acute asthma at the pediatric intensive care unit: can we link the clinical phenotypes to immunological endotypes?
Sarah van den Berga Department of Respiratory Medicine, Amsterdam Institute for Infection and Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands;b Departmentof Pediatric Pulmonology, Amsterdam Public Health Institute, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands Simone Hashimotoa Department of Respiratory Medicine, Amsterdam Institute for Infection and Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, The...
Prediction of asthma in early preschool wheezing by electronic nose analysis
LETTER TO THE EDITOR Niels Rutjes, Corresponding Author n.w.rutjes@amsterdamumc.nl orcid.org/0000-0002-3996-1963 Department of Paediatric Pulmonology, Amsterdam UMC Location AMC, Amsterdam, The Netherlands Correspondence Niels W. Rutjes, Department of Pediatric Pulmonology, AUMC, University of Amsterdam, Amsterdam, Netherlands.
Poor outcome of SARS-CoV-2 infection in patients with severe asthma on biologic therapy
Highlights • Severe asthma patients on biologics might be more susceptible for COVID-19. • SARS-CoV-2 is not an important trigger for asthma exacerbations in these patients. • Severe COVID-19 may be more frequent in asthma patients on biologic therapy. • Contributing factors may be the commonly observed co-morbidities such as obesity.
Young children experience little emotional burden during invasive procedures in asthma research
Our results indicate that undergoing clinical research procedures does not increase reluctance to undergo future medical procedures. The anticipatory anxiety experienced by many children is likely a consequence of having a limited understanding of the nature and impact of hospital procedures. This is underpinned by our observation that informing children about the venipuncture has a positive impact on how they experience the procedure.
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