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Articles by Simone Kersten
Author Correction: Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
Correction to: Nature Cell Biology https://doi.org/10.1038/s41556-021-00654-5, published online 1 April 2021. In the version of the article initially published, in Extended Data Fig. 7h, the first two α-pEGFR panels (WT and NRASQ61H) were copies of α-pEGFR panels 3 and 4 (KRASG12C and KRASG12V). Extended Data Fig. 7h has now been updated with the correct WT and NRASQ61H blots in the HTML and PDF versions of the article. About this article Ponsioen, B., Post, J.B., Buissant des Amorie, J.R. et al.
Transcription-based identification of uncharacterized genes in the human immune response
Abstract Host-pathogen interactions are shaped by the nature of the pathogen and by host-related factors. Human host responses can be characterized in microbe-stimulated immune cells using transcriptomics. We set out to characterize gene expression changes as a result of microbial in vitro stimulation in medium-cultured human primary immune cells, using four pathogen ligands representing bacteria (LPS and S. aureus), viruses (Poly(I:C)) and fungi (C.
Expanding the PRAAS spectrum: De novo mutations of immunoproteasome subunit β-type 10 in six infants with SCID-Omenn syndrome
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Multi-omic profiling of pathogen-stimulated primary immune cells
Abstract Objectives: To perform long-read transcriptome and proteome profiling of pathogen-stimulated peripheral blood mononuclear cells (PBMCs) from healthy donors. We aim to discover new transcripts and protein isoforms expressed during immune responses to diverse pathogens.
SUsPECT: A pipeline for variant effect prediction based on custom long-read transcriptomes for improved clinical variant annotation
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Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
Abstract Direct targeting of the downstream mitogen-activated protein kinase (MAPK) pathway to suppress extracellular-regulated kinase (ERK) activation in KRAS and BRAF mutant colorectal cancer (CRC) has proven clinically unsuccessful, but promising results have been obtained with combination therapies including epidermal growth factor receptor (EGFR) inhibition.
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