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Articles by Simone Kosol
Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research
1 Bacterial Pathogens, Molecular Targets, Resistances and the Drug Development Process In the fight against bacterial infections, particularly those caused by multi-resistant pathogens known as “superbugs”, the need for new antibacterials is undoubted in scientific communities and is by now also widely perceived in the general public. However, the antibacterial research landscape has changed considerably over the past years.
Gene amplifications cause high-level resistance against albicidin in gram-negative bacteria
Loading metrics Open Access Peer-reviewed Research Article Citation: Saathoff M, Kosol S, Semmler T, Tedin K, Dimos N, Kupke J, et al. (2023) Gene amplifications cause high-level resistance against albicidin in gram-negative bacteria. PLoS Biol 21(8): e3002186. https://doi.org/10.1371/journal.pbio.3002186 Academic Editor: Csaba Pál, Biological Research Centre, HUNGARY Received: October 4, 2022; Accepted: June 7, 2023; Published: August 10, 2023 Copyright: © 2023 Saathoff et al.
Transcription activation by the resistance protein AlbA as a tool to evaluate derivatives of the antibiotic albicidin
Transcription activation by the resistance protein AlbA as a tool to evaluate derivatives of the antibiotic albicidin† Simone Kosol,a Lida Rostock,a Jonas Barsig, a Theresa Tabarelli,a Kay Hommernick,a Marcel Kulike,a Tobias Eulberg,a Maria Seidel,a Iraj Behroz,a Leonardo Kleebauer,a Stefan Grätz,a Andi Mainza and Roderich D. Süssmuth *a Abstract The rising numbers of fatal infections with resistant pathogens emphasizes the urgent need for new antibiotics.
The occurrence of ansamers in the synthesis of cyclic peptides - Nature Communications
Abstract α-Amanitin is a bicyclic octapeptide composed of a macrolactam with a tryptathionine cross-link forming a handle. Previously, the occurrence of isomers of amanitin, termed atropisomers has been postulated. Although the total synthesis of α-amanitin has been accomplished this aspect still remains unsolved. We perform the synthesis of amanitin analogs, accompanied by in-depth spectroscopic, crystallographic and molecular dynamics studies.
Gene amplifications cause high-level resistance against albicidin in Gram-negative bacteria
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Iodine-Mediated Tryptathionine Formation Facilitates the Synthesis of Amanitins
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2021, XXXX, XXX RETURN TO ARTICLES ASAPPREVArticleNEXT Guiyang Yao, Caroline H. Knittel Caroline H. Knittel Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 124, 10623 Berlin, Germany , Simone Kosol Simone Kosol Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 124, 10623 Berlin, Germany , Marius T. Wenz Marius T.
In Vitro Biosynthetic Studies of Bottromycin Expand the Enzymatic Capabilities of the YcaO Superfamily
The bottromycins belong to the ribosomally synthesized and posttranslationally modified peptide (RiPP) family of natural products. Bottromycins exhibit unique structural features, including a hallmark macrolactamidine ring and thiazole heterocycle for which divergent members of the YcaO superfamily have been biosynthetically implicated.
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