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Articles by Simone Schmid
Multi-omics integration unravels four molecular subgroups of corticotroph pituitary neuroendocrine tumours with distinct clinicopathological features
Abstract Corticotroph pituitary neuroendocrine tumours (PitNETs)/adenomas are heterogeneous sellar neoplasms. Currently established histopathological classification approaches are often considered limited in fully capturing the clinical and biological complexity of these tumours.
Distinct molecular subgroups in pediatric and young-onset meningiomas require age-adapted risk stratification
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Abstract Meningiomas in pediatric and adolescent/young adult patients are poorly characterized biologically and clinically, and risk stratification is largely extrapolated from adult tumors. We analyze 293 tumors from patients aged 0–39 years using integrated histopathological and molecular profiling.
By Arnault Tauziède-Espariat, Thomas Hielscher, Daniel Schrimpf, Kirsten Göbel, Eric Y. Stutheit-Zhao, Lukas Friedrich, Felix Keller, Fuat Kaan Aras, Filippo Nozzoli, Dominik Sturm, Christine White, Simone Schmid, Christian Mawrin, Julia E. Neumann, Rudi Beschorner, Christian Hartmann, Mariette Kranendonk, Sybren L. N. Maas, Eelke M Bos, Eleonora Aronica, Saskia M Peerdeman, Nikki B. Thuijs, Angelika Mühlebner, Benno Kusters, Cinzia E. Lavarino, Stéphanie Puget, Jason Chiang, Sonika Dahiya, Melike Pekmezci, Arie Perry, Miriam Ratliff, Christel Herold-Mende, Sandro M. Krieg, Wolfgang Wick, Stefan M. Pfister, Pieter Wesseling, Andreas von Deimling, Pascale Varlet, Felix Sahm, Philipp Sievers, Natalie Berghaus, Dilan Savran, Irem Saribiyik, Arda Inan, Ayça Erşen-Danyeli, Wilfred F. A. den Dunnen, Oluwadamilola Akanji
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Nature
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Single nucleus RNA profiling reveals potential therapeutic vulnerabilities in sinonasal carcinomas
Abstract Sinonasal undifferentiated carcinomas are rare, aggressive tumors with limited treatment options. Molecular subgroups defined by IDH2 mutations or SWI/SNF complex deficiencies have recently been recognized, but therapeutic implications remain unclear. We performed single-nucleus RNA sequencing on 12 FFPE tumors (six IDH2 mutated (IDH2mt), six SMARCA4 mutated (SMARCA4mt)), generating 59,612 nuclei.
Spearfishing and public health promotion: A cross-sectional analysis of the Hawaiʻi Behavioral Risk Factor Surveillance System Survey
Loading metrics Open Access Peer-reviewed Research Article Citation: Hansen L, Wu YY, Sentell TL, Thompson M, St. John TL, Schmid S, et al. (2025) Spearfishing and public health promotion: A cross-sectional analysis of the Hawaiʻi Behavioral Risk Factor Surveillance System Survey. PLoS ONE 20(3): e0319169. https://doi.org/10.1371/journal.pone.0319169 Editor: Christopher A.
Meeting report of the 20th International Congress of Neuropathology (ICN) 2023 in Berlin
1 INTRODUCTION AND PROLOGUE Exactly 62 years to the month after the 4th International Congress of Neuropathology (ICN) took place from September 4th to 8th 1961 at the Ludwig Maximilian University of Munich, the global neuropathological community—or, more accurately, its neuropathological children and grandchildren—returned back to the 20th ICN, that is, ICN2023, in Berlin/Germany (12–16 September 2023).
Schlangen an der Kasse machen klug
Wer sich nicht mehr langweilen kann, wird zum Zombie. Immer noch schneller als Selfscanning: Der herkömmliche Verkauf im Supermarkt. Foto: Keystone Selbstbedienungskassen sind beliebt in der Schweiz. Jeder Zweite hat schon zum Scanner gegriffen, und viele Kunden haben Spass daran, ein bisschen Kassierer zu spielen. Offenbar macht es den meisten nichts aus, dass sie damit Gratisarbeit für Grossunternehmen leisten und helfen, Personal einzusparen.
miR-149 Suppresses Breast Cancer Metastasis by Blocking Paracrine Interactions with Macrophages
Tumor Biology and Immunology Ismael Sánchez-González, Anja Bobien, Christian Molnar, Simone Schmid, Michaela Strotbek, Melanie Boerries, Hauke Busch and Monilola A. Olayioye DOI: 10.1158/0008-5472.CAN-19-1934 Published March 2020 Abstract Paracrine activation of cells contained in the tumor microenvironment promotes tumor progression and metastasis.
miR-149 Suppresses Breast Cancer Metastasis by Blocking Paracrine Interactions with Macrophages
Tumor Biology and Immunology Ismael Sánchez-González, Anja Bobien, Christian Molnar, Simone Schmid, Michaela Strotbek, Melanie Boerries, Hauke Busch and Monilola A. Olayioye DOI: 10.1158/0008-5472.CAN-19-1934 Abstract Paracrine activation of cells contained in the tumor microenvironment promotes tumor progression and metastasis. In breast cancer, malignant cells recruit and educate macrophages into a M2 tumor–promoting phenotype that supports the metastatic spread of cancer cells.
miR-149 Suppresses Breast Cancer Metastasis by Blocking Paracrine Interactions with Macrophages
Tumor Biology and Immunology Ismael Sánchez-González, Anja Bobien, Christian Molnar, Simone Schmid, Michaela Strotbek, Melanie Boerries, Hauke Busch and Monilola A. Olayioye DOI: 10.1158/0008-5472.CAN-19-1934 Abstract Paracrine activation of cells contained in the tumor microenvironment promotes tumor progression and metastasis. In breast cancer, malignant cells recruit and educate macrophages into a M2 tumor–promoting phenotype that supports the metastatic spread of cancer cells.
miR-149 suppresses breast cancer metastasis by blocking paracrine interactions with macrophages
Research Article Ismael Sánchez-González, Anja Bobien, Christian Molnar, Simone Schmid, Michaela Strotbek, Melanie Boerries, Hauke Busch and Monilola A Olayioye DOI: 10.1158/0008-5472.CAN-19-1934 Abstract Paracrine activation of cells contained in the tumor microenvironment promotes tumor progression and metastasis. In breast cancer, malignant cells recruit and educate macrophages into a M2 tumor-promoting phenotype that supports the metastatic spread of cancer cells.
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