Abstract Purpose: Anemia is a recognized complication of hypothyroidism, but disease-level genetic studies have not identified a clear erythroid cell-intrinsic target. We integrated genetic validation, molecular-QTL prioritization, and replicated triiodothyronine (T3)-responsive erythroid experiments to identify candidates linking hypothyroidism liability to anemia. Materials and methods: Two-sample Mendelian randomization (MR) assessed genetically predicted hypothyroidism and anemia.
